Alzheimer's disease continues to be one of the most puzzling conditions in elderly care. However, researchers have been working to try and better understand the illness.
According to the study out of the University of Western Ontario, scientists have discovered more about the spatial memory issues that are associated with Alzheimer's. The study's authors focused on the changes that occur with acetylcholine (ACh), a neurotransmitter.
The researchers created a mouse that didn't produce enough ACh and found that it could cause problems with spatial memory. Additionally, the study's authors noted this problem was related to hyperactivity, a symptom typically experienced by Alzheimer's patients.
"Once we reproduced that neurochemical failure, we asked, 'how does that affect spatial memory, how does it affect learning?' We found mice that don't have that particular chemical messenger in specific areas of the brain, have problems with spatial memory, for example," said Marco Prado. "This reveals specific types of cognitive deficits that we can hope to improve with drugs that boost this chemical messenger."
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